Detalhe da pesquisa
1.
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.
Annu Rev Pharmacol Toxicol
; 62: 211-233, 2022 01 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34990205
2.
Early Appearance of Dendritic Alterations in Neocortical Pyramidal Neurons of the Ts65Dn Model of Down Syndrome.
Dev Neurosci
; 44(1): 23-38, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-34852343
3.
Treatment with the flavonoid 7,8-Dihydroxyflavone: a promising strategy for a constellation of body and brain disorders.
Crit Rev Food Sci Nutr
; 62(1): 13-50, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-32914634
4.
Early postnatal oleic acid administration enhances synaptic development and cognitive abilities in the Ts65Dn mouse model of Down syndrome.
Nutr Neurosci
; 25(7): 1400-1412, 2022 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-33345728
5.
Obstructive sleep apneas naturally occur in mice during REM sleep and are highly prevalent in a mouse model of Down syndrome.
Neurobiol Dis
; 159: 105508, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34509609
6.
Early appearance of developmental alterations in the dendritic tree of the hippocampal granule cells in the Ts65Dn model of Down syndrome.
Hippocampus
; 31(4): 435-447, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33464704
7.
Neonatal therapy with clenbuterol and salmeterol restores spinogenesis and dendritic complexity in the dentate gyrus of the Ts65Dn model of Down syndrome.
Neurobiol Dis
; 140: 104874, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32325119
8.
CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder.
Hum Mol Genet
; 27(9): 1572-1592, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29474534
9.
Prenatal, but not Postnatal, Curcumin Administration Rescues Neuromorphological and Cognitive Alterations in Ts65Dn Down Syndrome Mice.
J Nutr
; 150(9): 2478-2489, 2020 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32729926
10.
Prenatal Administration of Oleic Acid or Linolenic Acid Reduces Neuromorphological and Cognitive Alterations in Ts65dn Down Syndrome Mice.
J Nutr
; 150(6): 1631-1643, 2020 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32243527
11.
Neonatal treatment with cyclosporine A restores neurogenesis and spinogenesis in the Ts65Dn model of Down syndrome.
Neurobiol Dis
; 129: 44-55, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31085229
12.
HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.
Hum Mol Genet
; 25(18): 3887-3907, 2016 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27466189
13.
Neuroanatomical alterations and synaptic plasticity impairment in the perirhinal cortex of the Ts65Dn mouse model of Down syndrome.
Neurobiol Dis
; 106: 89-100, 2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28651891
14.
Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome.
Neurobiol Dis
; 103: 11-23, 2017 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-28359846
15.
New Perspectives for the Rescue of Cognitive Disability in Down Syndrome.
J Neurosci
; 35(41): 13843-52, 2015 Oct 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26468184
16.
Correction: Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation.
J Biol Chem
; 295(11): 3746, 2020 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32169856
17.
Correction: CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3ß/ß-catenin signaling.
J Biol Chem
; 295(10): 3388, 2020 Mar 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32144151
18.
Withdrawal: Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation.
J Biol Chem
; 295(10): 3391, 2020 03 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32144154
19.
Withdrawal: The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome.
J Biol Chem
; 295(10): 3392, 2020 03 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32144155
20.
SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation.
Glia
; 64(8): 1437-60, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27270750